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Is it necessary to prefreeze the material of the lyophilizer?
release time:2022-07-04  |  Browse:1273

Freeze drying machine is a technology that uses the principle of sublimation for drying. It quickly freezes the dried substance at low temperature, and then in an appropriate vacuum environment, the frozen water molecules are directly sublimated into water vapor to escape. The products obtained by freeze-drying/freeze-drying machine are called freeze-drying products, and this process is called freeze-drying.


The application of freeze-drying technology in biological products, Western medicine production, traditional Chinese medicine production, medical treatment, and food freeze-drying. When working, lift the material rack out of the cold trap chamber and place it on a spare movable hard plastic disc (all placed above the cold trap chamber). Then cover the organic glass cover well. If a gland device is used to freeze dry the material, after the material is pre frozen, quickly transfer the material from the pre frozen rack to the shelf of the gland device, and then cover the organic glass cover used for the gland.


The entire freeze-drying process of the freeze-drying machine is carried out in a low-temperature and low-pressure environment, and the freeze-drying method can effectively retain the thermosensitive components and original biological characteristics of the freeze-drying product. The freeze-drying process is a process of gradually increasing temperature from low temperature. If the temperature rises too fast or too high, it can easily lead to the appearance collapse and poor appearance of the final freeze-drying product. The freeze-drying process is divided into three stages: pre freezing, sublimation drying, and analytical drying.


The work of a freeze-drying machine is to directly sublimate the solvent from a solid sample to a gaseous state under vacuum to achieve drying. Due to drying the sample at room temperature or even low temperature, it does not affect its biological activity, and the treated sample is in a loose and porous state, which is easy to dissolve. So freeze-drying is a good method for preserving bioactive samples.


Material pre freezing of freeze-drying machine:

The pre freezing of materials is a Committed step in the freeze-drying process, and the quality of freeze-drying products is directly affected by the quality of the pre freezing process. The pre freezing process of materials can be basically divided into slow freezing and fast freezing. Users can flexibly operate the equipment according to specific needs to achieve effective pre freezing of materials. For example:


1.Slow freezing: Place pre prepared materials into a cold trap, cover the insulation cover, open the compressor, and pre freezing begins;


2. Quick freezing: First turn on the compressor, wait for the temperature of the cold trap chamber to drop to a certain temperature, and then put the pre prepared materials into the cold trap to start pre freezing;


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